good producer  Tamoxifen citrate 54965-24-1  trader

Beluga chemical professional supply P2NP CAS：705-60-2 1-Phenyl-2-nitropropene

Why choose Beluga chemical

1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities.

2. Made in China and exported to many countries and regions at the most favorable price.

3、Our customers all over the world and have been highly valued and trusted by customers

4、We promise to reply your inquiry within 24 hours, including holidays and holidays.

5, safe and prudent shipping a variety of transportation modes for you to choose.

If you are interested, please feel free to contact us for detailed product specifications, prices, delivery times and payment terms.

Tamoxifen citrate (tamoxifencitrate, TCT for short), is an estrogen (estrogen) competitive antagonist, is a non-steroidal anti-estrogen drug, can interact with estrogen (estradiol) in the body Competitively, it binds to the estrogen receptor of breast cancer cells, thereby inhibiting the effect of estrogen on cancer cells, blocking the growth and development of tumor cells, and exerting anti-cancer effects. It is often used clinically to treat various types of breast cancer, especially for postmenopausal women with breast cancer who are positive for estrogen receptor and progesterone receptor and have low prostate-specific antigen levels.

Mechanism

TCT has cis-trans isomers, and its cis-isomers show weak estrogenic effects, while the trans-isomers have anti-estrogen effects. Tamoxifen binds to estrogen receptor (ER) in the cytoplasm when used in the early application or in the presence of low concentration, so it exhibits weak estrogen effect. After TCT enters the nucleus, it inhibits the transcription and synthesis of ER in the nucleus, which can produce a lasting anti-estrogen effect. In the study, it was found that many new functions of TCT are related to the mechanism of action outside of competition with estrogen receptor-membrane regulation mechanism. As a membrane regulator, TCT can reduce cell circulation. On this basis, TCT can also be used as an antioxidant to protect cell membranes and human low-density lipoproteins from oxidative damage.